Download Files:
Semilicoisoflavone B
$220 – $750
Products Details
Product Description
– Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation[1].
Web ID
– HY-N1280
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C20H16O6
References
– [1]Gu MY, et al. <i>Glycyrrhiza uralensis</i> and Semilicoisoflavone B Reduce Aβ Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression. Mol Nutr Food Res. 2018 Mar;62(6):e1700633.
CAS Number
– 129280-33-7
Molecular Weight
– 352.34
Compound Purity
– 99.0
SMILES
– O=C1C(C2=CC(O)=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC(O)=C14
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Amyloid-β
Pathway
– Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
