Semaxinib
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Semaxinib

SKU T2064-5 mg Category Brand:

Price range: 70 CAD through 379 CAD

Products Details

Product Description

– Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRβ, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.

Web ID

– T2064

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H14N2O

Citations

– 1. Chen F, Shi Q, Pei F, et al. A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infection. Molecular Systems Biology. 2021, 17(8): e10239 2. Huang X, Zhu J, Jiang Y, et al. SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells. Drug Design, Development and Therapy. 2019, 13: 1763 3. Lei W, Xu H, Yao H, et al.5α-Hydroxycostic acid inhibits choroidal neovascularization in rats through a dual signalling pathway mediated by VEGF and angiopoietin 2.Molecular Medicine.2023, 29(1): 1-13. 4. Li M Y, Gao R P, Zhu Q, et al.Skeletal muscle-derived FSTL1 starting up angiogenesis by regulating endothelial junction via activating Src pathway can be upregulated by hydrogen sulfide.American Journal of Physiology-Cell Physiology.2023, 325(5): C1252-C1266.

References

– Fong TA, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res, 1999, 59(1), 99-106.

CAS Number

– 204005-46-9

Molecular Weight

– C15H14N2O

Compound Purity

– 0.9984

SMILES

– C(=C1C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C

Target

– ADC Cytotoxin

Pathway

– Tyrosine Kinase/Adaptors|||Angiogenesis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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