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Seco-DUBA
$1,180 – $3,850
Products Details
Product Description
– Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
Web ID
– HY-132180A
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H23ClN4O4
References
– [1]Elgersma RC, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985. Mol Pharm. 2015;12(6):1813-1835.|[2]Platform Technologies in Drug Discovery and Validation
CAS Number
– 1227961-59-2
Molecular Weight
– 526.97
Compound Purity
– 95.81
SMILES
– O=C(NC1=CN2C(C=C1)=NC(C(N3C[C@@H](CCl)C4=C3C=C(O)C5=CC=CC(C)=C45)=O)=C2)C6=CC=C(O)C=C6
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– ADC Cytotoxin
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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