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Scutellarin
Price range: 72 CAD through 277 CAD
Products Details
Product Description
– Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signaling in HCC cells.
Web ID
– T2789
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H18O12
Citations
– 1. Chinnasamy S, Selvaraj G, Selvaraj C, et al. Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2). International Journal of Biological Macromolecules. 2020, 144: 53-66
2. Yang X, Liu L, Hao Y, et al. A Bioluminescent Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and In Vitro. Viruses. 2021, 13(6): 1055.
3. Deng G, Zheng B, Dou M, et al.Scutellarin alleviates renal ischemia–reperfusion injury by inhibiting the MAPK pathway and pro‐inflammatory macrophage polarization.The FASEB Journal.2024, 38(13): e23769.
4. Huang B, Lin B, Zheng H, et al.Discovery of natural products as influenza neuraminidase inhibitors: in silico screening, in vitro validation, and molecular dynamic simulation studies.Molecular Diversity.2025: 1-17.
References
– Ke Y, et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochem Biophys Res Commun. 2016 Dec 18. pii: S0006-291X(16)32174-X.
CAS Number
– 27740-01-8
Molecular Weight
– C21H18O12
Compound Purity
– 0.9975
SMILES
– O[C@H]1[C@H](Oc2cc3oc(cc(=O)c3c(O)c2O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O
Pathway
– Stem Cells|||Proteases/Proteasome|||Cytoskeletal Signaling|||Microbiology/Virology|||JAK/STAT signaling|||PI3K/Akt/mTOR signaling
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
