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SCR7 pyrazine
$94 – $616
Products Details
Product Description
– SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity[1][2].
Web ID
– HY-107845
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H12N4OS
Citations
– Int J Mol Sci. 2022, 23(14), 7518.|BMC Biotechnol. 2021 Jul 27;21(1):45.|EMBO Rep. 2019 Mar;20(3):e46821.|J Genet Genomics. 2021 Mar 30.|J Immunol. 2020 Apr 1;204(7):1904-1918.|J Immunother Cancer. 2022 Jan;10(1):e003809.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Onco Targets Ther. 2018 Aug 17;11:4945-4953.|Sens Actuators B Chem. 19 February 2022, 131598.|Viruses. 2023 Nov 14, 15(11), 2256.
References
– [1]Srivastava M, et al. An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012 Dec 21;151(7):1474-87.|[2]Lin C, et al. Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells. Sci Rep. 2016 Oct 7;6:34531.
CAS Number
– 14892-97-8
Molecular Weight
– 332.38
Compound Purity
– 99.96
SMILES
– O=C1NC(NC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C12)=S
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Apoptosis;CRISPR/Cas9;DNA/RNA Synthesis
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
