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Products Details
Product Description
– SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2].
Web ID
– HY-106975
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C16H23NO3S2
References
– [1]Thompson JS, et, al. Neutral endopeptidase inhibition increases the potency of ANP in isolated rat pulmonary resistance vessels and isolated blood perfused lungs. Pulm Pharmacol. 1995 Apr-Jun;8(2-3):143-7.|[2]Watkins RW, et, al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68.
CAS Number
– 144505-58-8
Molecular Weight
– 341.49
SMILES
– CSCC[C@@H](C(O)=O)NC([C@@H](CS)CC1=C(C=CC=C1)C)=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Neprilysin
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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