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SCH-1473759 (hydrochloride)
$144 – $2,376
Products Details
Product Description
– SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.
Web ID
– HY-10483
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H27ClN8OS
References
– [1]Yu T, et al. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.|[2]Basso AD, et al. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.
CAS Number
– 1094067-13-6
Molecular Weight
– 463.00
Compound Purity
– 99.79
SMILES
– [H]Cl.CC1=CN2C(C(NC3=CC(CN(C(C)(CO)C)CC)=NS3)=N1)=NC=C2C4=CNN=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 7.14 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Aurora Kinase
Isoform
– Aurora A;Aurora B
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
