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SB-743921 (free base)
SKU
HY-14661-Get quote
Category Reference compound
Tags Cancer, Cell Cycle/DNA Damage;Cytoskeleton, Kinesin
Products Details
Product Description
– SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases[1][2].
Web ID
– HY-14661
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H33ClN2O3
References
– [1]Good JA, et al. Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem. 2013 Mar 14;56(5):1878-93.|[2]Jeffrey R. Jackson, et al. A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, Sep 12-15, 2006.|[3]Yin Y, et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015 Jun;56(6):1813-20.
CAS Number
– 618430-39-0
Molecular Weight
– 517.06
SMILES
– O=C1C(CC2=CC=CC=C2)=C([C@@H](C(C)C)N(C(C3=CC=C(C)C=C3)=O)CCCN)OC4=CC(Cl)=CC=C41
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Kinesin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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