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Saquinavir (mesylate)
$35 – $209
Products Details
Product Description
– Saquinavir Mesylate (Ro 31-8959/003) is an HIV protease inhibitor used in retrovirus research.
Web ID
– HY-17003
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C39H54N6O8S
Citations
– bioRxiv. 2020 Apr.|Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00872-20.|Antiviral Res. 2022 Nov 10;105463.|Exp Cell Res. 2019 Oct 1;383(1):111488.|Int J Antimicrob Agents. 2019 Dec;54(6):814-819.|J Med Chem. 2021 Mar 11;64(5):2725-2738.|J Pharm Sci. 2017 Sep;106(9):2839-2846.|Nat Commun. 2020 Sep 4;11(1):4417.|Phytomedicine. 2019 Mar 15;56:175-182. |Signal Transduct Target Ther. 2021 May 29;6(1):212.
References
– [1]Kaldor et al (1995) Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett. 5 721.|[2]Yerino GA, Halabe EK, Zini E, Feleder EC.
Bioequivalence study of two oral tablet formulations containing saquinavir mesylate boosted with ritonavir in healthy male subjects.
Arzneimittelforschung. 2011;61(8):481-7.|[3]Branham ML, Moyo T, Govender T.
Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement.
Eur J Pharm Biopharm. 2012 Jan;80(1):194-202.|[4]Brouwers J, Vermeire K, Grammen C, Schols D, Augustijns P.
Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir.
Antiviral Res. 2011 Aug;91(2):217-23.|[5]Knechten H, Lutz T, Pulik P, Martin T, Tappe A, Jaeger H.
Safety and Efficacy in HIV-1-Infected Patients Treated with Ritonavir-Boosted Saquinavir Mesylate.
CAS Number
– 149845-06-7
Molecular Weight
– 766.95
Compound Purity
– 99.89
SMILES
– CS(=O)(O)=O.O=C(C1=NC2=C(C=CC=C2)C=C1)N[C@@H](CC(N)=O)C(N[C@@H](CC3=CC=CC=C3)[C@H](O)CN4[C@@H](C[C@@]5([H])[C@@](CCCC5)([H])C4)C(NC(C)(C)C)=O)=O
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– DMSO : 20 mg/mL (ultrasonic)
Target
– Autophagy;HIV;HIV Protease
Isoform
– HIV-1;HIV-2
Pathway
– Anti-infection;Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
