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Sabeluzole
$187
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Products Details
Product Description
– Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer’s disease[1][2].
Web ID
– HY-105022
Shipping
– Room temperature
Molecular Formula
– C22H26FN3O2S
References
– [1]Hlinák Z,et al. Sabeluzole improves social recognition and antagonizes chlordiazepoxide’s effect on habituation in the rat. Psychopharmacology (Berl). 1991;104(4):505-9. |[2]Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103.
CAS Number
– 104383-17-7
Molecular Weight
– 415.52
SMILES
– CN(C1CCN(CC(O)COC2=CC=C(F)C=C2)CC1)C3=NC4=C(C=CC=C4)S3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Tau Protein
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
