Download Files:
(S)-Verapamil (hydrochloride)
$250 – $2,350
Products Details
Product Description
– (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].
Web ID
– HY-135336A
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H39ClN2O4
References
– [1]Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.|[2]Tannergren C, et al. St John’s wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.
CAS Number
– 36622-28-3
Molecular Weight
– 491.06
Compound Purity
– 99.39
SMILES
– COC1=C(OC)C=CC(CCN(C)CCC[C@@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C)C)=C1.Cl
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 200 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– Apoptosis;Calcium Channel;Leukotriene Receptor
Isoform
– Calcium Channel;LTC4
Pathway
– Apoptosis;GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
