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(S)-(+)-Rolipram
SKU
HY-B0392-10 mg
Category Reference compound
Tags Apoptosis;Metabolic Enzyme/Protease, Apoptosis;Phosphodiesterase (PDE), Cancer; Inflammation/Immunology; Neurological Disease
$77 – $820
Products Details
Product Description
– (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells[1][2][3].
Web ID
– HY-B0392
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C16H21NO3
References
– [1]Ortmann R, et, al. Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats. Psychopharmacology (Berl). 1986;89(3):273-7.|[2]Semmler J, et, al. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells. Int J Immunopharmacol. 1993 Apr;15(3):409-13.|[3]Wachtel H. Neurotropic effects of the optical isomers of the selective adenosine cyclic 3′,5′-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo. J Pharm Pharmacol. 1983 Jul;35(7):440-4.
CAS Number
– 85416-73-5
Molecular Weight
– 275.34
Compound Purity
– 99.77
SMILES
– O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Apoptosis;Phosphodiesterase (PDE)
Isoform
– PDE4
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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