(S)-(+)-Rolipram

$77$820

Products Details

Product Description

– (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells[1][2][3].

Web ID

– HY-B0392

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C16H21NO3

References

– [1]Ortmann R, et, al. Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats. Psychopharmacology (Berl). 1986;89(3):273-7.|[2]Semmler J, et, al. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells. Int J Immunopharmacol. 1993 Apr;15(3):409-13.|[3]Wachtel H. Neurotropic effects of the optical isomers of the selective adenosine cyclic 3′,5′-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo. J Pharm Pharmacol. 1983 Jul;35(7):440-4.

CAS Number

– 85416-73-5

Molecular Weight

– 275.34

Compound Purity

– 99.77

SMILES

– O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1

Clinical Information

– No Development Reported

Research Area

– Cancer; Inflammation/Immunology; Neurological Disease

Solubility

– DMSO : 100 mg/mL (ultrasonic)

Target

– Apoptosis;Phosphodiesterase (PDE)

Isoform

– PDE4

Pathway

– Apoptosis;Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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