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(S)-Ro 32-0432
SKU
HY-108601A-1 mg
Category Reference compound
Tags Epigenetics;TGF-beta/Smad, Inflammation/Immunology; Neurological Disease, PKC
$850
Only 1000 item(s) left in stock.
Products Details
Product Description
– (S)-Ro 32-0432 is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].
Web ID
– HY-108601A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H29ClN4O2
References
– [1]A M Birchall, et al. Ro 32-0432, a Selective and Orally Active Inhibitor of Protein Kinase C Prevents T-cell Activation. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.|[2]Thakur Gurjeet Singh, et al. Ro 32-0432 Attenuates Mecamylamine-Precipitated Nicotine Withdrawal Syndrome in Mice. Naunyn Schmiedebergs Arch Pharmacol. 2013 Mar;386(3):197-204.
CAS Number
– 1781828-85-0
Molecular Weight
– 489.01
SMILES
– O=C(C(C1=C(C[C@@H](CN(C)C)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– PKC
Isoform
– PKCα;PKCβ;PKCγ;PKCε
Pathway
– Epigenetics;TGF-beta/Smad
Product type
– Reference compound
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