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(S)-Amisulpride
$90 – $1,800
Products Details
Product Description
– (S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects[1][2].
Web ID
– HY-126068
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H27N3O4S
References
– [1]Timothy J Donahue, et al. (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics. Eur J Pharmacol. 2014 Jul 5;734:15-22.|[2]Vincent Grattan, et al. Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D<sub>2</sub> and D<sub>3</sub>, while R Enantiomers Engage 5-HT<sub>7</sub>. ACS Omega. 2019 Aug 15;4(9):14151-14154.
CAS Number
– 71675-92-8
Molecular Weight
– 369.48
Compound Purity
– 99.75
SMILES
– O=C(C1=CC(S(=O)(CC)=O)=C(C=C1OC)N)NC[C@H]2N(CCC2)CC
Clinical Information
– Phase 3
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Dopamine Receptor
Isoform
– 5-HT7 Receptor;D2 Receptor;D3 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
