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Products Details
Product Description
– RXR antagonist 2 (compound 6b) is a potent antagonist of RXR with a Ki and Kd of 0.391 and 0.281 μM. RXR antagonist 2 has the potential for the research of RXR related diseases[1].
Web ID
– HY-144383
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C29H35F3N2O3
References
– [1]Watanabe M, et al. Increased Molecular Flexibility Widens the Gap between Ki and Kd values in Screening for Retinoid X Receptor Modulators. ACS Med Chem Lett. 2022 Jan 21;13(2):211-217.
Molecular Weight
– 516.60
SMILES
– FC(F)(F)C1=NC2=C(C=CC(C(O)=O)=C2)N1C3=CC(C(C)(CCC4(C)C)C)=C4C=C3OCCCCCC
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– RAR/RXR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
