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RU.521
Price range: 66 CAD through 1,342 CAD
Products Details
Product Description
– RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
Web ID
– T5486
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H12Cl2N4O3
Citations
– 1. Li B, Xu L, Wang Z, et al.Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway.Cellular and Molecular Neurobiology.2024, 44(1): 36.
2. Wang Z, Zhang X, Luo Y, et al.Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis).Cell Death & Disease.2024, 15(5): 375.
References
– Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.
CAS Number
– 2262452-06-0
Molecular Weight
– C19H12Cl2N4O3
Compound Purity
– 0.9982
SMILES
– Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1
Pathway
– Immunology/Inflammation|||DNA Damage/DNA Repair
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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