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Products Details
Product Description
– RORγt inverse agonist 14 (8e) is a potent, orally active and selective RORγt inverse agonist (EC50 of 2.5 nM) with anti-inflammatory activity. RORγt inverse agonist 14 is used in the study for rheumatoid arthritis and psoriasis[1].
Web ID
– HY-132195
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H26F8N2O6S2
References
– [1]Qingjie Liu, et al. Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis. ACS Med Chem Lett. 2021 Apr 30;12(5):827-835.
CAS Number
– 2672496-70-5
Molecular Weight
– 678.61
SMILES
– O=C(N[C@@H]1CC[C@@]2(S(=O)(C3=CC=C(F)C=C3)=O)C4=C(N=C(C(C(F)(F)F)(F)C(F)(F)F)C=C4)CC[C@]21[H])[C@](C)(O)CS(=O)(C)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– ROR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
