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Products Details
Product Description
– RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor. RORγt/DHODH-IN-2 can be used for inflammatory bowel disease (IBD) research[1].
Web ID
– HY-142834
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H30N4OS
References
– [1] Ji-An Chen, et al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615.
CAS Number
– 2641758-86-1
Molecular Weight
– 434.60
SMILES
– O=C(N1CCN(CC2=CC=CC(NC3=NC4=CC=CC=C4S3)=C2C)CC1)C5CCCC5
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Dihydroorotate Dehydrogenase;ROR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
