Rolapitant hydrochloride
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Rolapitant hydrochloride

SKU T3724-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 248 CAD through 3,168 CAD

Products Details

Product Description

– Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting, and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM, which does not interact with CYP3A4 and demonstrates potent centrally-mediated anti-emetic activity in both acute and delayed ferret emesis models [1] [2].

Web ID

– T3724

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H27ClF6N2O2

Citations

– 1. Sanders D W, Jumper C C, Ackerman P J, et al. SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. Elife. 2021, 10: e65962.

References

– Rapoport B, Schwartzberg L, Chasen M, Powers D, Arora S, Navari R, Schnadig I. Eur J Cancer. 2016 Apr;57:23-30.

CAS Number

– 858102-79-1

Molecular Weight

– C25H27ClF6N2O2

Compound Purity

– 0.9846

SMILES

– Cl.C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

Pathway

– GPCR/G Protein|||Neuroscience

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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