Ro-3306
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Ro-3306

SKU T2356-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 51 CAD through 1,390 CAD

Products Details

Product Description

– RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.

Web ID

– T2356

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H13N3OS2

Citations

– 1. Zhang Y, Hong X, Hua S, et al. Reconstitution and mechanistic dissection of the human microtubule branching machinery. Journal of Cell Biology. 2022, 221(7): e202109053 2. Chen C, Zhang X, Wang Y, et al. Translational and Post-translational Control of Human Naïve versus Primed Pluripotency. iScience. 2021: 103645. 3. Ou J, Li H, Qiu P, et al. CDK9 modulates circadian clock by attenuating REV-ERBα activity. Biochemical and Biophysical Research Communications. 2019 Jun 11;513(4):967-973 4. Guo S, Lei X, Chang Y, et al.SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis.Signal Transduction and Targeted Therapy.2022, 7(1): 1-12. 5. Jiang L, Yu Y, Li Z, et al.BMS-265246, a Cyclin-Dependent Kinase Inhibitor, Inhibits the Infection of Herpes Simplex Virus Type 1.Viruses.2023, 15(8): 1642.

References

– Yang W, et al. Accumulation of cytoplasmic Cdk1 is associated with cancer growth and survival rate in epithelial ovarian cancer. Oncotarget. 2016 Aug 2;7(31):49481-49497.

CAS Number

– 872573-93-8

Molecular Weight

– C18H13N3OS2

Compound Purity

– 0.9866

SMILES

– O=C1N=C(NCc2cccs2)SC1=Cc1ccc2ncccc2c1

Pathway

– Cytoskeletal Signaling|||Cell Cycle/Checkpoint|||Apoptosis|||MAPK|||Chromatin/Epigenetic|||Metabolism|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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