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Products Details
Product Description
– Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM)[1].
Web ID
– HY-107696
Shipping
– Room temperature
Molecular Formula
– C19H23Cl2NO2
References
– [1]Mutel V, et al. In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J Neurochem. 1998 May;70(5):2147-55. |[2]Li MH, et al. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017 Jun;42(7):1539-1547. |[3]deBacker J, et al. GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology. 2015 Jan;40(2):394-405.
CAS Number
– 64047-73-0
Molecular Weight
– 368.30
SMILES
– ClC(C=C1)=CC=C1CCC2C3=CC(O)=C(OC)C=C3CCN2C.Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– iGluR
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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