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Products Details
Product Description
– Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM)[1].
Web ID
– HY-107696
Shipping
– Room temperature
Molecular Formula
– C19H23Cl2NO2
References
– [1]Mutel V, et al. In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J Neurochem. 1998 May;70(5):2147-55. |[2]Li MH, et al. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017 Jun;42(7):1539-1547. |[3]deBacker J, et al. GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology. 2015 Jan;40(2):394-405.
CAS Number
– 64047-73-0
Molecular Weight
– 368.30
SMILES
– ClC(C=C1)=CC=C1CCC2C3=CC(O)=C(OC)C=C3CCN2C.Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– iGluR
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
