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RNF5 inhibitor inh-02
Price range: 1,466 CAD through 3,184 CAD
Products Details
Product Description
– RNF5 inhibitor inh-02, a potent E3 ubiquitin ligase RNF5/RMA1 inhibitor, demonstrates significant efficacy in rescuing F508del-CFTR with an EC50 of 2.2 uM in bronchial epithelial cells homozygous for the F508del mutation. This compound is valuable for cystic fibrosis research[1].
Web ID
– T35883
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C23H20N4S
References
– Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8.
CAS Number
– 324579-65-9
Molecular Weight
– C23H20N4S
SMILES
– N(C(=NC1=CC=CC=C1)C2=CC=CC=C2)=C3N(CC4=CC=CC=C4)C(C)=NS3
Target
– RAAS
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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