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Products Details
Product Description
– RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species[1].
Web ID
– HY-155804
Shipping
– Room temperature
Molecular Formula
– C18H19F2N5O2
References
– [1]Harris PA, et al. Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J Med Chem. 2019 May 23;62(10):5096-5110.
CAS Number
– 2226735-54-0
Molecular Weight
– 375.37
SMILES
– O=C(C1CCN(C2=NN=C(O2)C)CC1)N3[C@H](C4=CC(F)=CC(F)=C4)CC=N3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Necroptosis;RIP kinase
Pathway
– Apoptosis
Product type
– Reference compound
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