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Rigosertib
Price range: 54 CAD through 155 CAD
Products Details
Product Description
– Rigosertib (ON-01910) is a selective, non-ATP-competitive PLK1 inhibitor (IC50: 9 nM) and multi-kinase inhibitor. As a selective anti-cancer agent, Rigosertib induces apoptosis by inhibiting the PI3 kinase/Akt pathway, promotes histone H2AX phosphorylation, and induces G2/M arrest in the cell cycle.
Web ID
– T16750
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H25NO8S
References
– Xu F, et al. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signalingtransduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310.
CAS Number
– 592542-59-1
Molecular Weight
– C21H25NO8S
Compound Purity
– 0.9953
SMILES
– C(=C/S(CC1=CC(NCC(O)=O)=C(OC)C=C1)(=O)=O)C2=C(OC)C=C(OC)C=C2OC
Target
– Others
Pathway
– Cell Cycle/Checkpoint|||Angiogenesis|||Cytoskeletal Signaling|||Apoptosis|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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