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Rhodiosin
$60 – $260
Products Details
Product Description
– Rhodiosin is a double inhibitor of CYP2D6 and AChE, and can be isolated from Rhodiolis rhodiolis root. The IC50 for CYP2D6 is 0.761 μM, and the Ki is 0.769 μM. Rhodiosin has antioxidant and neuroprotective activity and can regulate HIF-1α signaling pathway to protect the central nervous system[1][2][3][4]
Web ID
– HY-N2425
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C27H30O16
References
– [1]Xu W, et al. Two potent cytochrome P450 2D6 inhibitors found in <i>Rhodiola rosea</i>. Pharmazie. 2013 Dec;68(12):974-6.|[2]Li FJ, et al. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of <i>Rhodiola crenulata</i> using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532.|[3]Yan X, et al. Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness. Pharm Biol. 2021 Dec;59(1):1540-1550.|[4]Kwon H J, et al. Rhodiosin, an antioxidant flavonol glycoside from Rhodiola rosea. Journal of the Korean Society for Applied Biological Chemistry, 2009, 52: 486-492
CAS Number
– 86831-54-1
Molecular Weight
– 610.52
Compound Purity
– 99.36
SMILES
– OC1=C2C(C(C(O)=C(C3=CC=C(O)C=C3)O2)=O)=C(O)C=C1O[C@H]4[C@@H]([C@@H]([C@@H](O)[C@H](C)O4)O[C@]5([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO)O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– Cholinesterase (ChE)
Isoform
– AChE
Pathway
– Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
