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Rhodionin
$331 – $571
Products Details
Product Description
– Rhodionin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.761 μM and a Ki of 0.769 μM[1]. Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL[2]. Rhodionin exhibits potent DPPH free radical scavenging activities, with an IC50 of 19.49 μM[3].
Web ID
– HY-N0241
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C21H20O11
References
– [1]Xu W, et al. Two potent cytochrome P450 2D6 inhibitors found in <i>Rhodiola rosea</i>. Pharmazie. 2013 Dec;68(12):974-6.|[2]Li FJ, et al. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of <i>Rhodiola crenulata</i> using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532.|[3]Choe KI, et al. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of <i>Rhodiola sachalinensis</i> A. BOR. Molecules. 2012 Sep 27;17(10):11484-94.
CAS Number
– 85571-15-9
Molecular Weight
– 448.38
Compound Purity
– 98.78
SMILES
– O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=C(O)C(O[C@H]4[C@@H]([C@@H]([C@H]([C@H](C)O4)O)O)O)=CC(O)=C13
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 16.67 mg/mL (ultrasonic)
Target
– Cholinesterase (ChE)
Isoform
– AChE
Pathway
– Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
