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Product Description
– RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.
Web ID
– T2378
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H35N7O4
References
– Cirstea D, et al. Leukemia. 2013 Dec;27(12):2366-75.
CAS Number
– 784210-88-4
Molecular Weight
– C29H35N7O4
Compound Purity
– 0.9991
SMILES
– COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1
Pathway
– Cell Cycle/Checkpoint|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling|||JAK/STAT signaling|||Angiogenesis|||MAPK|||Chromatin/Epigenetic|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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