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RG7800
$80 – $450
Products Details
Product Description
– RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.
Web ID
– HY-101792
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C24H28N6O
Citations
– bioRxiv. 2020 Feb.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Life Sci Alliance. 2019 Mar 25;2(2):e201800268.|Nature. 2021 Aug;596(7871):291-295.|Patent. US20230340498A1.
References
– [1]Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100.
CAS Number
– 1449598-06-4
Molecular Weight
– 416.52
Compound Purity
– 99.86
SMILES
– O=C1C=C(C2=NN3C(C(CC)=NC(C)=C3)=C2)N=C4N1C=C(C5CCN(C)CC5)C=C4C
Clinical Information
– Phase 1
Research Area
– Others
Solubility
– DMSO : 1.4 mg/mL (ultrasonic;warming)|Ethanol : 2.5 mg/mL (ultrasonic)|H2O : 1.25 mg/mL (ultrasonic;adjust pH to 3 with HCl)
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
