Reversine
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Reversine

SKU T1825-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 51 CAD through 661 CAD

Products Details

Product Description

– Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).

Web ID

– T1825

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H27N7O

Citations

– 1. Carlos J A E G, Lima K, Coelho-Silva J L, et al. Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia. Cellular Oncology. 2020: 1-11 2. Lima K, Carlos J A E G, de Melo Alves-Paiva R, et al. Reversine exhibits antineoplastic activity in JAK2 V617F-positive myeloproliferative neoplasms. Scientific Reports. 2019, 9(1): 9895 3. Tan M, Ren F, Yang X. Anti-HBV therapeutic potential of small molecule 3, 5, 6, 7, 3′, 4′-Hexamethoxyflavone in vitro and in vivo. Virology. 2021 4. Hirakata, Camila, et al. Targeting glioma cells by antineoplastic activity of reversine. Oncology Letters. 22.2 (2021): 1-9 5. Hirakata, Camila, et al. Targeting glioma cells by antineoplastic activity of reversine. Oncology Letters. 22.2 (2021): 1-9 6. Parducci N S, Garnique A D M B, Lima K, et al.Antineoplastic effects of pharmacological inhibitors of aurora kinases in CSF3RT618I-driven cells.Blood Cells, Molecules, and Diseases.2023: 102799.

References

– Chen S, et al. J Am Chem Soc. 2004, 126(2), 410-411.

CAS Number

– 656820-32-5

Molecular Weight

– C21H27N7O

Compound Purity

– 0.9975

SMILES

– C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2[nH]cnc12

Target

– Others

Pathway

– Chromatin/Epigenetic|||Neuroscience|||Autophagy|||Cell Cycle/Checkpoint|||GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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