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Products Details
Product Description
– RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].
Web ID
– HY-108636
Shipping
– Room temperature
Molecular Formula
– C11H11NO3S2
References
– [1]J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.
CAS Number
– 1036069-26-7
Molecular Weight
– 269.34
SMILES
– OC1=CC=C(C(CSC2=NCCS2)=O)C=C1O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
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