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Retaspimycin (Hydrochloride)
$108 – $1,512
Products Details
Product Description
– Retaspimycin Hydrochloride is a potent inhibitor of Hsp90 with EC50s of 119 nM for both Hsp90 and Grp9.
Web ID
– HY-10210
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C31H46ClN3O8
Citations
– FASEB J. 2023 Mar;37(3):e22832.|Theranostics. 2019 Aug 12;9(20):5769-5783.|Transl Oncol. 2019 Apr 3;12(6):801-809.
References
– [1]Scaltriti M, et al. Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer. Mol Cancer Ther. 2011 May;10(5):817-24.|[2]Patterson J, et al. IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells. Cancer Chemother Pharmacol. 2008 May;61(6):923-32.|[3]Sydor JR, et al. Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17408-13. Epub 2006 Nov 7.
CAS Number
– 857402-63-2
Molecular Weight
– 624.17
Compound Purity
– 95.77
SMILES
– O=C(NC1=C2O)/C(C)=C/C=C[C@H](OC)[C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](CC2=C(C(O)=C1)NCC=C)C)OC)O)C)OC(N)=O.Cl
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– 1M HCl : 100 mg/mL (ultrasonic;adjust pH to 1 with 1M HCl)|DMSO : 60 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic)
Target
– HSP
Isoform
– HSP90
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
