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RepSox
Price range: 48 CAD through 1,061 CAD
Products Details
Product Description
– RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.
Web ID
– T6337
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C17H13N5
Citations
– 1. Ma X, Lu Y, Zhou Z, Human expandable pancreatic progenitor–derived β cells ameliorate diabetes. Science Advances. 2022, 8(8): eabk1826.
2. Wang W, Ren S, Lu Y, et al. Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production. The EMBO Journal. 2021 Jun 1;40(11):e106771. doi: 10.15252/embj.2020106771. Epub 2021 Apr 28.
3. Li J, Bai Y, Liu Y, et al.Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems.Cell Reports.2023, 42(6).
4. Zhang S, Lou H, Lu H, et al.Characterization of Proliferation Medium and Its Effect on Differentiation of Muscle Satellite Cells from Larimichthys crocea in Cultured Fish Meat Production.Fishes.2023, 8(9): 429.
5. Xin Q, Niu R, Chen Q, et al.Stable cytoactivity of piscine satellite cells in rice bran-gelatin hydrogel scaffold of cultured meat.International Journal of Biological Macromolecules.2024: 134242.
6. Lou H, Lu H, Zhang S, et al.Highly aligned myotubes formation of piscine satellite cells in 3D fibrin hydrogels of cultured meat.International Journal of Biological Macromolecules.2024: 136879.
7. Zhang S, Lu H, Lou H, et al.An efficient serum-free medium for ex vivo expansion of myoblasts from Larimichthys crocea for cultured meat production.Food Research International.2024, 196: 115073.
8. Qin X, Fu L, Li C, et al.Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling.Science China Life Sciences.2025: 1-15.
References
– Tu WZ, et al. RepSox, a small molecule inhibitor of the TGFβ receptor, induces brown adipogenesis and browning of white adipocytes. Acta Pharmacol Sin. 2019 Dec;40(12):1523-1531.
CAS Number
– 446859-33-2
Molecular Weight
– C17H13N5
Compound Purity
– 0.9973
SMILES
– Cc1cccc(n1)-c1n[nH]cc1-c1ccc2ncccc2n1
Pathway
– Angiogenesis|||Stem Cells|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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