Refametinib

SKU HY-14691-10 mg Category Tags , ,

$96$624

Products Details

Product Description

– Refametinib (BAY 869766; RDEA119) is an orally available, potent, non-ATP-competitive, selective, allosteric MEK1/MEK2 inhibitor with IC50s of 19 nM and 47 nM, respectively.

Web ID

– HY-14691

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C19H20F3IN2O5S

References

– [1]Iverson C, et al. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009 Sep 1;69(17):6839-47.

CAS Number

– 923032-37-5

Molecular Weight

– 572.34

Compound Purity

– 99.82

SMILES

– O=S(C1(C[C@H](O)CO)CC1)(NC(C(NC(C(F)=C2)=CC=C2I)=C3F)=C(OC)C=C3F)=O

Clinical Information

– Phase 2

Research Area

– Cancer

Solubility

– DMSO : ≥ 31 mg/mL

Target

– MEK

Isoform

– MEK1;MEK2

Pathway

– MAPK/ERK Pathway

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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