Download Files:
RBN-3143
$260 – $2,100
Products Details
Product Description
– RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation[1].
Web ID
– HY-150207
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C22H28FN3O4S
References
– [1]Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal 2022 60: 4642.
CAS Number
– 2360853-16-1
Molecular Weight
– 449.54
Compound Purity
– 99.24
SMILES
– O=C1NC(CSC2CCOCC2)=NC3=CC(OCC4CCN(CC4)C(C)=O)=CC(F)=C13
Clinical Information
– Phase 1
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– PARP
Isoform
– PARP1;PARP10;PARP14;PARP15;PARP2;PARP3;PARP4
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
