RAS inhibitor Abd-7

SKU T36641-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 1,198 CAD through 4,000 CAD

Size

2 mg 1 mL * 10 mM (in DMSO)100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].

Web ID

– T36641

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H25N3O3

References

– Quevedo CE, et al. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun. 2018;9(1):3169. Published 2018 Aug 9.

CAS Number

– 2351843-48-4

Molecular Weight

– C23H25N3O3

SMILES

– COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.