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Raltegravir
$77 – $385
Products Details
Product Description
– Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.
Web ID
– HY-10353
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C20H21FN6O5
Citations
– Bioorg Med Chem. 2019 Sep 1;27(17):3836-3845. |Clin Drug Investig. 2019 Mar;39(3):285-299. |J Infect Dis. 2022 Sep 19;jiac386.|J Mol Biol. 2022 Feb 22;167507.|J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.|J Virol. 2017 Jan 18;91(3). pii: e02152-16.|Life Sci. 9 September 2022, 120948.|Molecules. 2022 Dec 12;27(24):8829.|PeerJ Physical Chemistry. 2019, 1:e6.|Pharmaceuticals. 2023 Aug 8, 16(8), 1118.|Phytomedicine. 2016 Nov 15;23(12):1383-1391. |SSRN. 2023 Mar 30.|Virol Sin. 2023 May 10;S1995-820X(23)00054-8.|Virology. 2023 Jun 21.|Viruses. 2021 Jan 18;13(1):E131.|Plant Biosyst. 2018, 1-8.|PLoS One. 2018 Mar 30;13(3):e0195168.
References
– [1]Moss DM, et al. Divalent metals and pH alter raltegravir disposition in vitro. Antimicrob Agents Chemother. 2012 Jun;56(6):3020-6|[2]Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.|[3]Hicks C, et al. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis. 2009 Apr 1;48(7):931-9|[4]Hare S, et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 Oct;80(4):565-72.|[5]Lewis, M.G., et al. Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology, 2010. 7: p. 21.|[6]Hare, S., et al., Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A, 2010. 107(46): p. 20057-62.
CAS Number
– 518048-05-0
Molecular Weight
– 444.42
Compound Purity
– 99.53
SMILES
– O=C(C(O)=C(C(NCC1=CC=C(C=C1)F)=O)N=C2C(C)(C)NC(C3=NN=C(C)O3)=O)N2C
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– HIV;HIV Integrase
Isoform
– HIV-1;HIV-2
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
