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Racecadotril-d5
SKU
HY-17399S-10 mg
Category Isotope-Labeled Compounds
Tags Isotope-Labeled Compounds;Neprilysin, Metabolic Disease, Metabolic Enzyme/Protease;Others
Products Details
Product Description
– Racecadotril-d5 is the deuterium labeled Racecadotril. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent[1].
Web ID
– HY-17399S
Shipping
– Room temperature
Molecular Formula
– C21H18D5NO4S
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Marion Eberlin, et al. A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor Racecadotril. Front Pharmacol. 2012 May 30;3:93.|[3]David W Griggs, et al. Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. J Pharmacol Exp Ther. 2016 May;357(2):423-31.
CAS Number
– 1246815-11-1
Molecular Weight
– 390.51
SMILES
– [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1COC(CNC(C(CSC(C)=O)CC2=CC=CC=C2)=O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;Neprilysin
Pathway
– Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
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