RA375
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RA375

SKU T36902-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 50 CAD through 496 CAD

Products Details

Product Description

– RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.

Web ID

– T36902

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H25ClN4O7

References

– Ravi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15(1):e0227727.

CAS Number

– 2649154-57-2

Molecular Weight

– C30H25ClN4O7

Compound Purity

– 0.9935

SMILES

– O=C(CCl)N[C@H](C(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=CC3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CC=CC=C4

Pathway

– Proteases/Proteasome|||Ubiquitination

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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