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Products Details
Product Description
– (R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects[1][2].
Web ID
– HY-107479
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C34H36FN5O2
References
– [1]Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. Psychopharmacology (Berl). 2010 Feb;208(2):265-77.|[2]Morales-Medina JC, et al. Chronic administration of the Y2 receptor antagonist, JNJ-31020028, induced anti-depressant like-behaviors in olfactory bulbectomized rat. Neuropeptides. 2012 Dec;46(6):329-34.
CAS Number
– 1094873-17-2
Molecular Weight
– 565.68
SMILES
– O=C(N(CC)CC)[C@@H](C1=CC=CC=C1)N2CCN(C3=CC=C(NC(C4=CC=CC=C4C5=CC=CN=C5)=O)C=C3F)CC2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Neuropeptide Y Receptor
Isoform
– NPY Y2 receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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