(R)-eIF4A3-IN-2

$480$4,200

Products Details

Product Description

– (R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1].

Web ID

– HY-43913

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Molecular Formula

– C25H19Br2ClN4O2

References

– [1]Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017;12(7):1760-1768.

CAS Number

– 2095484-82-3

Molecular Weight

– 602.70

Compound Purity

– 95.0

SMILES

– O=C(N1C[C@@H](C2=CC=C(Cl)C=C2)N(C(C3=CC=C(Br)C=C3)=O)CC1)C4=C5C=CC(Br)=CN5N=C4

Clinical Information

– No Development Reported

Research Area

– Others

Solubility

– DMSO : 50 mg/mL (ultrasonic)

Target

– Eukaryotic Initiation Factor (eIF)

Isoform

– eIF4

Pathway

– Cell Cycle/DNA Damage

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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