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QX77
$90 – $850
Products Details
Product Description
– QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells[1]. QX77 can impede self-renewal and promote differentiation of ES cells[2].
Web ID
– HY-112483
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H13ClN2O2
References
– [1]Jinzhong Zhang, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346|[2]Yi Xu, et al. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369(6502):397-403.
CAS Number
– 1798331-92-6
Molecular Weight
– 300.74
Compound Purity
– 99.59
SMILES
– CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 15 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Autophagy
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
