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Quiflapon
Price range: 50 CAD through 363 CAD
Products Details
Product Description
– Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotriene biosynthesis (LT) inhibitor (IC50: 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively).
Web ID
– T16087
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C34H35ClN2O3S
Citations
– 1. Nasri M, Dannenmann B, Doll L, et al.Flavopiridol restores granulopoiesis in experimental models of severe congenital neutropenia.Molecular Therapy.2024
References
– Brideau C, et al. Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807.
CAS Number
– 136668-42-3
Molecular Weight
– C34H35ClN2O3S
Compound Purity
– 0.9888
SMILES
– CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12
Target
– Others
Pathway
– Apoptosis|||Immunology/Inflammation
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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