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QO 58
$120 – $1,050
Products Details
Product Description
– QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability[1].
Web ID
– HY-110162
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H8Cl2F4N4O
References
– [1]Zhang F, et al. Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol. 2013;168(4):1030-1042.
CAS Number
– 1259536-62-3
Molecular Weight
– 443.18
Compound Purity
– 98.92
SMILES
– O=C1C=C(C2=C(Cl)N=C(Cl)C(F)=C2)NC3=C(C(C(F)(F)F)=NN13)C4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 62.5 mg/mL
Target
– Potassium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
