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Pyridone 6
Price range: 120 CAD through 3,168 CAD
Products Details
Product Description
– Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.
Web ID
– T3080
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H16FN3O
Citations
– 1. Li Y, Chen W, Zhu X, et al.Neuronal BST2: A Pruritic Mediator Alongside PAR2 in the Interleukin-27-Driven Itch Pathway.Journal of Investigative Dermatology.2024
References
– Nakagawa R, et al. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J Immunol. 2011 Nov 1;187(9):4611-20.
CAS Number
– 457081-03-7
Molecular Weight
– C18H16FN3O
Compound Purity
– 0.987
SMILES
– CC(C)(C)c1nc2c([nH]1)c1ccc(F)cc1c1c2cc[nH]c1=O
Pathway
– Chromatin/Epigenetic|||JAK/STAT signaling|||Angiogenesis|||Stem Cells|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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