PVZB1194

$50$180

Products Details

Product Description

– PVZB1194 is a biphenyl-type inhibitor of Kinesin spindle protein Eg5 or KIF11. Eg5 is related to the cell cycle, and Eg5 inhibition can lead to cell cycle arrest and apoptosis. PVZB1194 exhibits anticancer potential via inhibiting Eg5 ATPase activity. PVZB1194 binds to the α4/α6 allosteric pocket, and shows ATP competetive activity[1].

Web ID

– HY-122247

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Molecular Formula

– C13H9F4NO2S

References

– [1]Yokoyama H, et al. Structural basis of new allosteric inhibition in Kinesin spindle protein Eg5. ACS Chem Biol. 2015 Apr 17;10(4):1128-36.

CAS Number

– 1141768-04-8

Molecular Weight

– 319.27

Compound Purity

– 99.90

SMILES

– O=S(C1=CC=C(C2=CC=C(C(F)(F)F)C(F)=C2)C=C1)(N)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 250 mg/mL (ultrasonic)

Target

– Kinesin

Isoform

– Kinesin-5/Eg5/KSP

Pathway

– Cell Cycle/DNA Damage;Cytoskeleton

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

My Cart
Close Wishlist
Close Recently Viewed
Categories

Please fill out this form to request the file. We will send it to your Email address shortly. Thanks.

Please enable JavaScript in your browser to complete this form.

=

Please fill out this form to request the pricing.
We will send it to your email address shortly.
Thanks.

Please enable JavaScript in your browser to complete this form.

=