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PVZB1194
$50 – $180
Products Details
Product Description
– PVZB1194 is a biphenyl-type inhibitor of Kinesin spindle protein Eg5 or KIF11. Eg5 is related to the cell cycle, and Eg5 inhibition can lead to cell cycle arrest and apoptosis. PVZB1194 exhibits anticancer potential via inhibiting Eg5 ATPase activity. PVZB1194 binds to the α4/α6 allosteric pocket, and shows ATP competetive activity[1].
Web ID
– HY-122247
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C13H9F4NO2S
References
– [1]Yokoyama H, et al. Structural basis of new allosteric inhibition in Kinesin spindle protein Eg5. ACS Chem Biol. 2015 Apr 17;10(4):1128-36.
CAS Number
– 1141768-04-8
Molecular Weight
– 319.27
Compound Purity
– 99.90
SMILES
– O=S(C1=CC=C(C2=CC=C(C(F)(F)F)C(F)=C2)C=C1)(N)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Kinesin
Isoform
– Kinesin-5/Eg5/KSP
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
