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Products Details
Product Description
– PTD10, a highly potent PROTAC BTK degrader, exhibits a DC50 of 0.5 nM and a KD of 2.28 nM. It effectively degrades BTK in Ramos and JeKo-1 cells with respective DC50 values of 0.5 nM and 0.6 nM. Additionally, PTD10 inhibits cell growth and triggers apoptosis through the activation of both the caspase-dependent and mitochondrial pathways, making it suitable for research on B-cell dysregulation [1].
Web ID
– T79201
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C49H51N11O8
CAS Number
– 2642231-19-2
Molecular Weight
– C49H51N11O8
SMILES
– O=C1C=2N(C3=C(C2)CC(C)(C)C3)CCN1C4=C(CO)C(=CC=N4)C=5C=C(NC6=CC=C(C=N6)N7[C@@H](C)CN(C(CNC8=C9C(C(=O)N(C9=O)C%10C(=O)NC(=O)CC%10)=CC=C8)=O)CC7)C(=O)N(C)C5
Pathway
– PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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