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PSI-7409 (tetrasodium)
$260 – $2,400
Products Details
Product Description
– PSI-7409 tetrasodium is an active 5′-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.
Web ID
– HY-15745A
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C10H12FN2Na4O14P3
Citations
– Asian J Pharm Sci. 21 October 2021.|Antiviral Res. 2020 Mar;175:104708.|Biochem Biophys Res Commun. 2022 Dec 8;641:50-56.|Cell. 2022 Nov 10;185(23):4347-4360.e17.|J Virol Methods. 2021 Sep 14;298:114283.|Microbiol Spectr. 2022 Aug 18;e0272922.
References
– [1]Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2′-deoxy-2′-fluoro-2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96.|[2]Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.
CAS Number
– 1621884-22-7
Molecular Weight
– 588.09
Compound Purity
– 98.10
SMILES
– O[C@@H]([C@@](C)(F)[C@H](N1C(NC(C=C1)=O)=O)O2)[C@H]2COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– H2O : 150 mg/mL (ultrasonic)
Target
– HCV
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
