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PSB-12379
$204 – $672
Products Details
Product Description
– PSB-12379, a nucleotide analogue, is a potent Ecto-5′-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human)[1][2].
Web ID
– HY-100747
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H23N5O9P2
References
– [1]X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 -Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Sanjay Bhattarai. Adv. Therap. 2019, 2, 1900075.|[2]Bhattarai S, et al. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58(15):6248-63.
CAS Number
– 1802226-78-3
Molecular Weight
– 515.35
Compound Purity
– 99.54
SMILES
– O=P(O)(O)CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– H2O : 125 mg/mL (ultrasonic)
Target
– CD73
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
