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Products Details
Product Description
– PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors[1].
Web ID
– HY-110092
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C10H11F2N2Na4O13P3S
References
– [1]El-Tayeb A, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90.|[2]Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther. 2018 Oct;190:24-80.
CAS Number
– 1657025-60-9
Molecular Weight
– 622.14
SMILES
– O[C@H]1[C@H](N2C(NC(C=C2)=S)=O)O[C@H](COP(OP(C(F)(F)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– P2Y Receptor
Isoform
– P2Y2 Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
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