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Products Details
Product Description
– PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study[1].
Web ID
– HY-155102
Shipping
– Room temperature
Molecular Formula
– C47H57N9O6S
References
– [1]Valdivia A, el at. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2). J Med Chem. 2023;66(14):9445-9465. doi:10.1021/acs.jmedchem.2c01859Valdivia A, Vagadia PP, Guo G, O’Brien E, Matei D, Schiltz GE. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2). J Med Chem. 2023;66(14):9445-9465. doi:10.1021/acs.jmedchem.2c01859
Molecular Weight
– 876.08
SMILES
– O=C(CCOCCN(C1=CC(C)=NC(NC2=CC=C(NC(CC3=CC=CC=C3)=O)C=C2)=N1)C)N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Glutaminase;PROTACs
Pathway
– Metabolic Enzyme/Protease;PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
